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KMID : 0191120080230030544
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Journal of Korean Medical Science
2008 Volume.23 No. 3 p.544 ~ p.547
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Newly Developed Multiple Myeloma in a Patient with Primary T-Cell Lymphoma of Bone
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Hwang Jun-Eul
Shim Hyun-Jeong
Lee Se-Ryeon
Lee Je-Jung
Kim Hyeoung-Joon
Kim Yeo-Kyeoung
Chung Ik-Joo
Kim Ok-Ki
Ahn Jae-Sook
Yang Duk-Hwan
Cho Sang-Hee
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Abstract
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Primary non-Hodgkin’s lymphoma of bone (PLB) is rare, and generally presents
as a single extensive and destructive bone lesion. Histopathologically, most cases
present as diffuse large B-cell lymphoma, and T-cell lymphoma is rare. By contrast,
multiple myeloma is a disease defined as the neoplastic proliferation of a single
clone of plasma cells producing a monoclonal immunoglobulin. We report a case
of multiple myeloma that developed during treatment of PLB in a type of T-cell. A
48-yr-old man was diagnosed as T-cell PLB, stage IE, 18 months ago. The patient
received the chemoradiotherapy and salvage chemotherapy for PLB. However,
the lymphoma progressed with generalized bone pain, and laboratory findings
showed bicytopenia and acute renal failure. On bone marrow biopsy, the patient
was diagnosed as having multiple myeloma newly developed with primary T-cell
lymphoma of bone. In spite of chemotherapy, the patient died of renal failure.
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KEYWORD
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Lymphoma, Non-Hodgkin, Multiple Myeloma, T-Cell Lymphoma of Bone
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